BioShock Game Guide/Walkthrough
Olympus Heights
Note that things will play out differently here depending on whether or not you've been harvesting or rescuing the Little Sisters. We had been rescuing, so we awoke to a safehouse that was full of little girls, with Tanenbaum watching over them from behind a pane of glass. She clued us in to what Fontaine had been doing to you all along, and sent one of the girls up to open the door to the sewers. Presumably the same basic chain of events occurs if you've been harvesting the girls, as well.
Up in the sewers, grab the gate crank from the ground and use it to open the door. That'll lead you up to Athena's Glory, a little highway waystation that Fontaine has turned into a turreted deathtrap. Try to hack the turrets, if possible, and clear it out.
Now, as you do all this, Fontaine will continually be reducing your maximum health. Don't worry about this too much--the effects are eventually reversible. However, if you spend an exorbitant amount of time exploring, you will find yourself with a very tiny health bar, so it's important to keep moving as best as you can. That basically entails leaving the Little Girls alone for now and keeping to the task assigned to you.
Mercury Suites
Your first goal here is to search Suchong's apartment in Mercury Suites and find a way to negate the mind control that you're being subjected to. Head to that location on your map and find the goal marker for Suchong's pad; it's on the western side of the ground floor here. (Do the usual hacking of the turrets and cameras on the ground floor before proceeding in.) There's also a Power to the People machine on the pillar in the center of the ground floor.
Explore Suchong's suite thoroughly, and you'll find a Clever Inventor tonic on a desk next to a glowing audio diary. The diary reveals that there is an antidote to the mind control that's being filtered throughout the station: the mysterious Lot 192. Two samples were known to exist, one in Suchong's lab, and another that used to be located in Tanenbaum's apartment, upstairs in Mercury Suites. We'll go for the latter one first.
Finding the Antidote
Head for the stairwell here and start climbing upwards. Although the goal on your map appears on the second floor, the door to Tenenbaum's apartment actually isn't openable there; you'll have to head to the third floor. Have Electro Bolt ready to zap the camera that overwatches the walkway up there. When you reach the balcony of the third floor, follow the path around to the northwestern corner, being sure to grab the audio diary of the paparrazi along the way. That'll reveal the door code to Fontaine's suite here.
When you reach Tenenbaum's apartment, exploring the upper floor will reveal that the antidote has been moved to Fontaine's penthouse suite. Return to the ground floor of the Suites and input 5744 into the door to unlock the elevator leading up.
Fontaine's Apartment
A fierce battle will ensue as you enter Fontaine's little area. You may want to whip out your crossbow and take out the camera on the far northern wall as soon as you arrive; that'll prevent it from locking onto you and summoning security bots. Apart from that, take out the splicers and the turret, then move through the northern door.
Head upstairs and find the small chamber off to the side of Fontaine's bedroom to obtain the Lot 192. It'll restore your health bar, but there's a side effect: you can't control what kind of plasmid you equip. You'll flip to a new plasmid, including some that you don't even own, once a minute or so. This effectively makes it impossible to plan ahead for fights, but no matter: you should be able to take on any enemy in the game with just your weapons at this point.
In order to restore your ability to control your plasmids, you'll have to find the second dose of Lot 192. It's in Suchong's lab, in Apollo Square. Before you leave, explore the rest of Mercury Suites for goodies. The main portion that you'll be interested in is Sander Cohen's apartment on the first floor. If you left Cohen alive back in Fort Frolic, he'll be here waiting for you. Kill the splicers near the piano to open the door to the second floor of his apartment, then take Cohen out and nab his Muse Key. There's also a Power to the People station in this locked area. You can't access it if you killed him earlier.
Anyway, when you're ready to move on, find the exit to Apollo Square, back a ways down the tram system.
Apollo Square
Head into the tramway here, being on the lookout for a Rosie that'll be set upon by a few splicers. Feel free to kill the Rosie after she's weakened up a bit for some more ADAM; you won't be able to spend it at a Gatherer's Garden until you find the next antidote, however.
Make your way through the dystopian Apollo Square and head towards the Artemis Suites, where Suchong's lab is located. He's on the second floor, so open the door, shoot out the trap bolt across the way, then dash across, blow up the turret, and sneak around to hack the camera. That'll cover your back. You'll find the second Lot 192 on Suchong's desk, alongside an interesting audio log. You can also grab a Medical Expert 3 tonic in his operating room.
After exploring the third floor of this area, return to Apollo Square. You can now spend your ADAM at the Gatherer's Garden, so if you have a stockpile, now would be the time to use it.
Hestia Chambers
Before leaving for Point Prometheus, there's one last optional area to explore: Fontaine's Center for the Poor, in Hestia Chambers. It's found to the south of the Rapture Metro, so head on in, if you wish.
The top floor of Hestia is Atlas' hideout; it has a substantial amount of weaponry in it, if you happen to be running low on ammo. If you take the stairs down from the fifth floor to the fourth, you can find a Power to the People machine. The other side of the fifth floor has a wooden barricade over the door; smash it with the wrench and drop down to find some first aid kits, then jump onto the windowsill and crawl through to drop back down.
When you're ready (and have freed the last Little Sisters here), head into the bathysphere leading to Point Prometheus. If you want to revisit any of the previous levels (say, if you left behind some Little Sisters), feel free to do so now.
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