| Title | Genre | Score | Release Date |
|---|---|---|---|
| Sarah's Emergency Room | Strategy | Canceled | |
| SaraSaraSasara | Adventure | Feb 27, 2009 | |
| Sarcoex is Haunted | Adventure | Jan 30, 2013 | |
| Sargon 4 | Board | Jan 1, 1989 | |
| Sargon V: World Class Chess | Board | 1991 | |
| SAS: Against All Odds | Modern First-Person Shooter | Oct 15, 2004 | |
| SAS: Secure Tomorrow | Modern First-Person Shooter | Oct 16, 2008 | |
| SATAZIUS | Shoot-'Em-Up | 7.0 | Dec 16, 2011 |
| Satisfashion | Puzzle | Feb 20, 2009 | |
| SATOMI: Yami no Kyouzou | Adventure | Feb 19, 1999 | |
| Saturday Night Speedway | Driving | 6.5 | Mar 4, 2004 |
| Savage 2: A Tortured Soul | Fantasy First-Person Shooter | Jan 16, 2008 | |
| Savage Skies | Jet Sim | Dec 30, 2001 | |
| Savage Warriors | 2D Fighting | Jan 1, 1995 | |
| Savage XR | Strategy | Dec 24, 2011 | |
| Savage: The Battle for Newerth | Fantasy First-Person Shooter | 7.1 | Sep 9, 2003 |
| Savage: The Ultimate Quest for Survival | Action | 4.5 | Mar 31, 1996 |
| Save Leopards | Strategy | TBA | |
| Save Our Spirit | Puzzle | Sep 26, 2009 | |
| Save Santi | Puzzle | Dec 1, 2012 | |
| Saviors | Action | TBA | |
| Saw | Horror Action Adventure | Oct 31, 2009 | |
| SBK 2011 | Motorcycle Racing | May 13, 2011 | |
| SBK Generations | Motorcycle Racing | Jun 1, 2012 | |
| SBK X: Superbike World Championship | Motorcycle Racing | Oct 19, 2010 | |
| SBK-08 Superbike World Championship | Motorcycle Racing | Aug 1, 2008 | |
| SBK-09 Superbike World Championship | Motorcycle Racing | May 29, 2009 | |
| Scallywag: In the Lair of the Medusa | Action | Sep 27, 2007 | |
| Scania Truck Driving Simulator: The Game | Driving | Jun 21, 2012 | |
| Scapeghost | Text Adventure | 1991 | |
| Scarab | Mech Sim | 7.3 | Mar 31, 1997 |
| Scarface: The World Is Yours | Modern Action Adventure | 6.0 | Oct 8, 2006 |
| Scarlet Blade | Fantasy Online Role-Playing | TBA | |
| Scarlet Legacy | Fantasy Online Role-Playing | TBA | |
| Scarlet Waves | Strategy | Canceled | |
| Scarlett | Adventure | May 26, 2006 | |
| Scarygirl | 2D Platformer | Mar 22, 2012 | |
| Scattergories | Board | Dec 22, 1999 | |
| Scavenger Hunter | Adventure | Dec 1, 2006 | |
| Scene It? Twilight | Trivia / Game Show | Mar 19, 2010 | |
| Scenic Railway | Train Sim | Jun 28, 2002 | |
| SCHAR: Blue Shield Alliance | Shoot-'Em-Up | Aug 28, 2012 | |
| Schein | Puzzle | TBA | |
| Schizm | Adventure | 7.8 | Oct 17, 2001 |
| Schlag den Raab | Trivia / Game Show | Sep 10, 2010 | |
| Schlag den Raab: Das 2. Spiel | Trivia / Game Show | Oct 14, 2011 | |
| Schlag den Raab: Das 3. Spiel | Trivia / Game Show | Sep 11, 2012 | |
| School 26 | Miscellaneous | TBA | |
| School House Shuffle | Puzzle | Sep 7, 2008 | |
| School Tycoon | Business Strategy | 6.9 | Jan 15, 2004 |
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