My Resident Evil series died after Resident Evil 3. Some people claim RE4 was the best but I believe that's the origin of Capcom's failure (esp. Plaga). RE4 was good but they should've not release it under the main storyline of Resident Evil. Predecessor RE5, RE6 are definitely failure copies of RE4; Capcom gave too much super abilities to main characters and turned game from Survival Horror to Survival Action.
If they are only targeting for mass, then they should keep doing what they are doing right now but the game value depreciate in short time (RE6: $59.99 - $39.99 in just 3 months LOL) then Capcom require to spam bunch of small Add-ons to cover up losses. They should definitely need to spend some time to develop next RE. Core Resident Evil fans are getting tired and out of patient.
If they are really thinking about rebooting Resident Evil, I think open world style is good consideration. RE4, RE5, RE6 storylines are so linear and way too scripted. I would love to see Resident Evil in massive map like Fallout series and Skyrim series. It would be very interesting if PC version of open-world RE is moddable like Bethesda games and Capcom officially support mods.
Lastly, Capcom, please stop adding bunch of short movies, cut scenes, and button smashing crap in the next Resident Evil series... people are tired of those "Hollywood Style Visual Effects" and smashing buttons... all the cut scenes give us too much information and game turns out very very very predictable...